Carboxyfullerenes as neuroprotective agents
نویسندگان
چکیده
منابع مشابه
Carboxyfullerenes as neuroprotective agents.
Two regioisomers with C3 or D3 symmetry of water-soluble carboxylic acid C60 derivatives, containing three malonic acid groups per molecule, were synthesized and found to be equipotent free radical scavengers in solution as assessed by EPR analysis. Both compounds also inhibited the excitotoxic death of cultured cortical neurons induced by exposure to N-methyl-D-aspartate (NMDA), alpha-amino-3-...
متن کاملNutraceutical Antioxidants as Novel Neuroprotective Agents
A variety of antioxidant compounds derived from natural products (nutraceuticals) have demonstrated neuroprotective activity in either in vitro or in vivo models of neuronal cell death or neurodegeneration, respectively. These natural antioxidants fall into several distinct groups based on their chemical structures: (1) flavonoid polyphenols like epigallocatechin 3-gallate (EGCG) from green tea...
متن کاملStatins as Potentially Neuroprotective Agents: A Review
Anuradha Patel1* and Sergey V Pisklakov2* 1Associate Professor, Section Chief, Pediatric Anesthesia, Department of Anesthesiology and Perioperative Care New Jersey School of Medicine, Newark, New Jersey, USA 2Assistant Professor, Director of Neuroanesthesia Service, Chairman of Clinical Competence Committee, Department of Anesthesiology and Perioperative Care, New Jersey School of Medicine, New...
متن کاملSOD activity of carboxyfullerenes predicts their neuroprotective efficacy: a structure-activity study.
Superoxide radical anion is a biologically important oxidant that has been linked to tissue injury and inflammation in several diseases. Here we carried out a structure-activity study on six different carboxyfullerene superoxide dismutase (SOD) mimetics with distinct electronic and biophysical characteristics. Neurotoxicity via N-methyl-D-aspartate receptors, which involves intracellular supero...
متن کاملNeuroprotective Agents in Glaucoma
1.1 Glaucoma as a neurodegenerative disorder Glaucoma is a multifactorial disease in which multiple genetic, systemic and environmental factors interact to precipitate the disease. Increased intraocular pressure (IOP) is believed to be one of the major factors responsible for glaucomatous cell death. (Guo et al., 2005). The axons of the optic nerve make a twisting exit through the fenestrated c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1997
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.94.17.9434